CMV research is relatively new in comparison with other diseases and illnesses with Dr. Hugo Ribbert first observing CMV cells in the kidneys of a stillborn baby back in 1881. Over the next 20 years, similar cells were found in the salivary glands of children who had died of various causes. In 1960, CMV was successfully isolated in the urine of infants with an active infection and Dr. Thomas Weller officially coined the term "cytomegalovirus”. In these last 55 years, definite strides have been made in the field of CMV research, including the development and administration of antiviral treatments and vaccine candidates. Read up on a few recent studies that are advancing the field of CMV research and check out the National Institutes of Health’s PubMed website to learn more.
A French study sought to determine the efficacy of CMV education counseling for pregnant women. The three-year CMV study tested pregnant women for CMV towards the end of their first trimester then followed with prevention education to those women who had never been exposed to CMV. Results found that fewer women went on to acquire CMV during pregnancy after adopting the recommended prevention measures.
A University of Alabama at Birmingham study found that an inexpensive polymerase chain-reaction (PCR)-based saliva swab test could help identify newborns with congenital CMV, who are at risk for developing hearing loss during childhood. Researchers report that this PCR test, costing only $2.50 to $3 per test, showed high sensitivity and specificity, identifying infected newborns with greater than 97 percent accuracy.
This randomized, placebo-controlled trial of valganciclovir found that extending treatment of infants born symptomatic with congenital CMV from the traditional six weeks to six months helped to improve hearing and developmental outcomes. The CMV study end points included change in hearing in the better ear (“best-ear” hearing) from baseline to 6 months as well as change in hearing from baseline to follow-up at 12 and 24 months.